| 发明名称 |
ABUSE-PROOFED ORAL DOSAGE FORM |
| 摘要 |
The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N. |
| 申请公布号 |
US2015024046(A1) |
申请公布日期 |
2015.01.22 |
| 申请号 |
US201414508262 |
申请日期 |
2014.10.07 |
| 申请人 |
GRÜNENTHAL GMBH |
发明人 |
BARTHOLOMÄUS Johannes;KUGELMANN Heinrich;ARKENAU-MARIC Elisabeth |
| 分类号 |
A61K9/20;A61K47/10;A61K47/38;A61K31/137 |
主分类号 |
A61K9/20 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. An abuse-proofed, oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, comprising (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol and/or at least one of the pharmaceutically acceptable salts or derivatives thereof (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, optionally physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N. |
| 地址 |
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