| 发明名称 |
GENETICALLY MODIFIED ORGANISM FOR THE PRODUCTION OF LIPIDS |
| 摘要 |
The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism. |
| 申请公布号 |
US2015024009(A1) |
申请公布日期 |
2015.01.22 |
| 申请号 |
US201414491212 |
申请日期 |
2014.09.19 |
| 申请人 |
Lang Christine;Raab Andreas |
发明人 |
Lang Christine;Raab Andreas |
| 分类号 |
C12P7/64;C12N9/04;C12P5/00;C12N15/81 |
主分类号 |
C12P7/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl-CoA:long-chain-alcohol O-acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, and wherein the activity of HMG-CoA-reductase (EC1.1.1.34), is increased in comparison with the corresponding wildtype organism. |
| 地址 |
Berlin DE |
