| 发明名称 |
Compositions and methods for treating hematologic cancers targeting the SIRPalpha - CD47 interaction |
| 摘要 |
<p>The invention relates to modulating the SIRPα-CD47 interaction in order to treat hematological cancer and compounds therefor. In some embodiments, there is provided methods and uses of SIRPαpolypeptides, fragments and fusion proteins for treating hematological cancer, preferably human acute myeloid leukemia.</p> |
| 申请公布号 |
AU2010246872(B2) |
申请公布日期 |
2015.01.22 |
| 申请号 |
AU20100246872 |
申请日期 |
2010.05.14 |
| 申请人 |
UNIVERSITY HEALTH NETWORK;THE HOSPITAL FOR SICK CHILDREN |
发明人 |
WANG, C. Y. JEAN;DICK, JOHN;DANSKA, JAYNE;JIN, LIQING;RAJAKUMAR, SUJEETHA;THEOCHARIDES, ALEXANDRE |
| 分类号 |
A61K38/45;A61K38/16;A61K47/48;A61P35/00;A61P35/02;C12Q1/68 |
主分类号 |
A61K38/45 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
