| 发明名称 |
Mito-Ob: A Transgenic Mouse Model for Obesity |
| 摘要 |
An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These mice begin to develop obesity as a result of mitochondrial remodeling (upregulation of mitochondrial biogenesis and function) in WAT. |
| 申请公布号 |
US2015026833(A1) |
申请公布日期 |
2015.01.22 |
| 申请号 |
US201414328888 |
申请日期 |
2014.07.11 |
| 申请人 |
University of Manitoba |
发明人 |
Ande Sudharsana R.;Mishra Suresh |
| 分类号 |
A01K67/027 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A transgenic mouse comprising increased adipose tissue mass as compared to a wild-type mouse of the same strain and an exogenous nucleic acid construct that comprises a promoter operably linked to a gene encoding prohibitin. |
| 地址 |
Winnipeg CA |
