Active Transdermal Medicament Patch and Circuit Board for Same

摘要

An active transdermal medicament patch includes a planar substrate with a therapeutic face releasably retainable against the skin of a patient. A return electrode and a medicament matrix susceptible to permeation by medicament are secured at separated locations on the therapeutic face and electrically conductively engage the skin. A detector monitors iontophoretic medicament migration into the skin. An integrator operating on the output of the detector produces a running cumulative total of the amount of medicament delivered during a plurality of temporally non-contiguous therapy subsessions. A circuit breaker terminates medicament migration, when the output of the integrator equals a predetermined medicament quantity. A timer active during medicament migration stimulates a driver to operate a light-emitting diode in a distinct delivery confirmation mode during each a sequence of non-overlapping predetermined therapy subsessions, respectively. A circuit board on the substrate in a compact, folded state bears interconnected electrical circuit components.

主权项

1. A transdermal medicament patch comprising:
(a) a flexible, planar biocompatible substrate having on one side thereof a therapeutic face configured for releasable retention against the skin of a patient; (b) a planar medicament matrix secured to said therapeutic face of said substrate interior the periphery thereof, said medicament matrix being susceptible to permeation by medicament, and said medicament matrix effecting electrically conductive engagement with the skin of the patient when said substrate is retained thereupon; (c) a return electrode on the same side of said substrate as said medicament matrix interior said periphery of said therapeutic face, said return electrode effecting electrically conductive engagement with the skin of the patient when said substrate is retained thereupon; (c) a power source carried on said substrate and being so electrically coupled between said medicament matrix and said return electrode as to cause iontophoretic migration of medicament from said medicament matrix into the skin of the patient; and (d) dosage control means carried non-removably on said substrate for limiting to a predetermined medicament quantity the total medicament migrated iontophoretically from said medicament matrix into the skin of the patient during a plurality of temporally non-contiguous therapy subsessions.