发明名称 |
HISTONE DEACETYLASE (HDAC) INHIBITOR UP-REGULATES CAR EXPRESSION AND TARGETED ANTIGEN INTENSITY, INCREASING ANTITUMOR EFFICACY |
摘要 |
Embodiments of the invention employ methods and compositions for enhancing potency of immune cells that express one or more therapeutic proteins. In certain cases, the methods modulate expression of a CAR transgene in an immune cell, such as a T cell. Specific embodiments employ the exposure of cells and/or individuals to be treated with the cells with an effective amount of at least one agent that upregulates expression of the therapeutic protein, such as a mitogen, histone deacetylase inhibitor, and or DNA methyltransferase inhibitor. |
申请公布号 |
US2015023937(A1) |
申请公布日期 |
2015.01.22 |
申请号 |
US201414335766 |
申请日期 |
2014.07.18 |
申请人 |
Baylor College of Medicine |
发明人 |
Vera Valdes Juan Fernando;Brenner Malcolm;Anurathapan Usanarat |
分类号 |
A61K38/17;A61K35/14;C12N5/0783;A61K31/706 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Houston TX US |