OPTICAL ISOMERS OF (+) AND (-)-BENZHYDRYL UREAS AND (+) AND (-)-1-[(3-CHLOROPHENYL)-PHENYL-METHYL] UREA, A PHARMACEUTICAL COMPOSITION BASED THEREON AND A METHOD FOR PRODUCING SAID OPTICAL ISOMERS

摘要

The invention relates to novel substances, and more particularly to optical isomers of (+) and (-)-benzhydryl ureas of formula (I) and (+) and (-)-1-[(3-chlorophenyl)-phenyl-methyl] urea, a pharmaceutical composition based thereon, and a method for producing said optical isomers and for using same on the basis of the different therapeutic activity exhibited. (I) Where R≠R' and are selected from the group comprising hydrogen, alkyl, halogen, nitro, amino, alkylamino and hydroxy groups and are situated in the ortho-, para- or meta-positions of the benzene rings. When racemic Halodif 1-[(3-chlorophenyl)-phenyl-methyl] urea was separated using the method according to the invention, optical isomers of (+) and (-)-1-[(3-chlorophenyl)-phenyl-methyl] urea (Halodif isomers) with different degrees of therapeutic activity were produced.