发明名称 |
Optimisation of expression of parvoviral rep and cap proteins in insect cells |
摘要 |
The present invention relates to the improved production of recombinant parvoviral virions in insect cells. In particular, the invention relates to an improved process for the production of recombinant parvoviral virions in insect cells, wherein the full/empty parvoviral virion ratio is increased. The invention also relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral Rep proteins that increase the productivity of parvoviral vectors. |
申请公布号 |
AU2009215987(B2) |
申请公布日期 |
2015.01.22 |
申请号 |
AU20090215987 |
申请日期 |
2009.02.19 |
申请人 |
UNIQURE IP B.V. |
发明人 |
BAKKER, ANDREW CHRISTIAN;NOORDMAN, YVET;HERMENS, WILHELMUS THEODORUS JOHANNES MARIA CHRISTIAAN |
分类号 |
C12N7/04;C07K14/015;C12N5/07;C12N5/10;C12N15/85;C12N15/864 |
主分类号 |
C12N7/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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