NOVEL PHOSPHODIESTERASE INHIBITORS AND USES THEREOF
摘要
The invention provides for novel benzonaphthyridine derivatives and compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the compounds are phosphodiesterase inhibitors. The invention further provides for methods for inhibition of phosphodiesterase comprising contacting phosphodiesterase with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. The invention further provides for methods for treatment of neurodegenerative diseases, increasing memory or long term potentiation with novel benzonaphthyridine derivatives or compositions comprising novel benzonaphthyridine derivatives. In some embodiments, the phosphodiesterase is PDE5.
申请公布号
WO2015009930(A2)
申请公布日期
2015.01.22
申请号
WO2014US47031
申请日期
2014.07.17
申请人
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;LANDRY, DONALD, W.;DENG, SHIXIAN;FIORITO, JOLE;ARANCIO, OTTAVIO;WASMUTH, ANDREW
发明人
LANDRY, DONALD, W.;DENG, SHIXIAN;FIORITO, JOLE;ARANCIO, OTTAVIO;WASMUTH, ANDREW