发明名称 |
Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or AHI1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalactitol, dibromodulcitol, or analogs or derivatives thereof |
摘要 |
<p>Methods and compositions suitable for the treatment of malignancies in subjects with a germline deletion polymorphism that blocks the activity of thymidine kinase inhibitors in triggering apoptosis in tumor cells or in subjects having a mutation in or a dysregulation of the</p> |
申请公布号 |
AU2013280644(A1) |
申请公布日期 |
2015.01.22 |
申请号 |
AU20130280644 |
申请日期 |
2013.06.24 |
申请人 |
BACHA, JEFFREY;BROWN, DENNIS;GARNER, WILLIAM;DEL MAR PHARMACEUTICALS |
发明人 |
BROWN, DENNIS M.;BACHA, JEFFREY A.;GARNER, WILLIAM J. |
分类号 |
A61K31/047;A61K38/12 |
主分类号 |
A61K31/047 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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