发明名称 |
Multivalent Antibody Complexes Targeting IGF-1R Show Potent Toxicity Against Solid Tumors |
摘要 |
The present invention concerns methods and compositions comprising an anti-IGF-1R antibody or fragment thereof for treatment of cancer or autoimmune disease. Preferably, the cancer is renal cell carcinoma, breast cancer or pancreatic cancer. The anti-IGF-1R antibody or fragment may be part of a complex, such as a DOCK-AND-LOCK™ (DNL™) complex. Preferably, the DNL™ complex also comprises a second antibody, a second antibody fragment, an affibody or a cytokine. More preferably, the cytokine is interferon-α2b. Most preferably, the second antibody, second fragment or affibody binds to IGF-1R, TROP2 or CEACAM6. The anti-IGF-1R antibody or complex may be administered alone or in combination with a therapeutic agent, such as an mTOR inhibitor. |
申请公布号 |
US2015024459(A1) |
申请公布日期 |
2015.01.22 |
申请号 |
US201414505595 |
申请日期 |
2014.10.03 |
申请人 |
IBC Pharmaceuticals, Inc. |
发明人 |
Chang Chien-Hsing;Goldenberg David M. |
分类号 |
C07K16/28;C07K14/56;A61K47/48;A61K51/10 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
1. A complex comprising:
(a) an anti-IGF-1R IgG antibody or antigen-binding fragment thereof attached to one or more anchor domain (AD) moieties from an AKAP protein; and (b) two or more copies of an effector attached to a dimerization and docking domain (DDD) moiety from a human protein kinase A (PKA) regulatory subunit RIα, RIβ, RIIα or RIIβ, wherein the effector is a second antigen-binding antibody fragment or a cytokine;wherein two copies of the DDD moiety form a dimer that binds to the AD moiety to form the complex. |
地址 |
Morris Plains NJ US |