发明名称 |
ANTIBODIES RECOGNIZING THE N-TERMINAL PART OF TISSUE FACTOR PATHWAY INHIBITOR CAPABLE OF ELICITING PRO-COAGULANT ACTIVITY |
摘要 |
The present invention relates to an antibody that specifically binds to an epitope in the N-terminal part (residues 1 to 79) of tissue factor pathway inhibitor (TFPI). An antibody according to the invention may be capable of neutralising TFPI inhibition of the TF/FVIIa complex, even in the presence of elevated levels of TFPI. Such antibodies may find utility in the treatment of subjects with a coagulopathy, such as those with haemophilia A or B, with or without inhibitors. |
申请公布号 |
WO2015007880(A1) |
申请公布日期 |
2015.01.22 |
申请号 |
WO2014EP65491 |
申请日期 |
2014.07.18 |
申请人 |
NOVO NORDISK A/S |
发明人 |
THORN CLAUSEN, JENS;OLSEN KROGH, BERIT;HEIBROCH PETERSEN, HELLE;AUGUSTSSON, CECILIA |
分类号 |
C07K16/38;A61K39/395 |
主分类号 |
C07K16/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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