METHOD AND SYSTEM FOR SYNTHESIZING NANOCARRIER BASED LONG ACTING DRUG DELIVERY SYSTEM FOR DEXAMETHASONE

摘要

The embodiments herein provide a nano-carrier system for delivering a long-acting injectable drug of dexamethasone and a method of synthesising the same. The dexamethasone entrapped nanoparticles are prepared using a lipid/phospholipid core which is coated by a polymer. The lipid and phospholipid are dissolved in organic solvent. This solution is transferred into an aqueous phase consisting of distilled water or a buffer. A solution of polymer is added drop wise. The drug entrapped nanoparticle formation is achieved by diffusion of the organic solvent within the aqueous solvent to obtain the nanoparticles. The drug gets entrapped within the nanoparticles via the anti-solvency effect of the aqueous matrix. The resulting drug nanocarriers are capable of releasing the drug in a slow rate upon injection. The synthesized drug carrying nanoparticles are cryopreserved stored for future administration. For better storage, the nanodispersion is dried to form a powder.

主权项

1. A method for synthesizing slow and controlled release of a dexamethasone entrapped in nanoparticle or nanocarrier, the method comprising steps of:
dissolving a dexamethasone in an organic solvent to get an organic solution, wherein the dexamethasone is dissolved at a concentration of 0.1 to 10 mg/ml in the organic solvent, and wherein a concentration of the organic solvent is 0.1 to 5 mg/ml; adding a phospholipid to the organic solution to form a bilayer around the dexamethasone; adding a lipid to the organic solution to obtain an organic solution mixture, wherein the organic solution mixture comprises organic solvent with the dexamethasone, phospholipid and lipid; adding the organic solution mixture by dropwise to an aqueous solution to form a lipid core, and wherein the aqueous solution is a water or a buffer, and wherein pH of the aqueous solution is in a range of 3-11, and wherein a volume ratio of the organic solution mixture to the aqueous solution is within 0.05 to 3; and adding a buffered solution of a polymer to the aqueous solution with lipid core to form a coating layer around the lipid core to obtain a nano carrier, and wherein pH of the polymer solution is in a range of 3.5 to 11, and wherein the polymer solution is added dropwise to the aqueous solution in a volume ratio of 0.05 to 1.