Allogeneic cellular immunotherapy for opportunistic infection

摘要

A method for stimulating the immune system in immunocompromised patients in order to treat opportunistic infection. The method involves the infusion of intentionally mismatched allogeneic cells. In order to prevent graft vs. host disease complications, the allogeneic cells can be irradiated prior to infusion.

主权项

1. A method of generating a de-novo Th1 anti-pathogen immunity in a host comprising:
inducing expression of Th1 cytokines; maintaining the Th1 cytokine environment during the activation of innate immune effector cells and until establishment of an anti-pathogen Th1 adaptive immune response wherein the host has a Th2-biased immunity.