发明名称 |
SENSITIZATION OF CANCER CELLS TO APOPTOSIS INDUCTION BY FLAVAGLINES AND 5-HYDROXY-FLAVONES |
摘要 |
The present invention relates to a combined preparation for simultaneous, separate or sequential use comprising at least one flavagline or a pharmaceutically acceptable salt thereof; and/or at least one 5-hydroxy-flavone or a pharmaceutically acceptable salt thereof; and at least one agent activating the intrinsic pathway of apoptosis for use in the treatment of cancer. The present invention further relates to a medicament comprising the combined preparation of the present invention, as well as to a kit comprising the combined preparation or a medicament according to the present invention and a means for administering at least one of its components. Moreover, the present invention relates to a method of inhibiting a cancer cell, comprising contacting said cancer cell with the combined preparation of the present invention, and thereby inhibiting said cancer cell. |
申请公布号 |
WO2015007714(A1) |
申请公布日期 |
2015.01.22 |
申请号 |
WO2014EP65095 |
申请日期 |
2014.07.15 |
申请人 |
DEUTSCHES KREBSFORSCHUNGSZENTRUM |
发明人 |
LI-WEBER, MIN;KRAMMER, PETER |
分类号 |
A61K31/343;A61K31/352;A61K31/496;A61K31/5377 |
主分类号 |
A61K31/343 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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