Systems and Methods for Sequential Windowed Acquisition Across a Mass Range Using an Ion Trap

摘要

Systems and methods are provided to perform sequential windowed acquisition of mass spectrometry data. A mass range and a mass window width parameter are received for a sample. A plurality of ions from the sample that are within the mass range are collected in an ion trap of a mass spectrometer. Two or more mass adjacent or overlapping windows are calculated to span the mass range using the mass window width parameter. Ions within each mass window are ejected from the ion trap. A mass spectrum is then detected from the ejected ions of the each mass window with a mass analyzer of the mass spectrometer, producing a collection of mass spectra for the mass range. The two or more mass windows can all have the same width, can all have different widths, or can have at least two mass windows with different widths.

主权项

1. A system for sequential windowed acquisition of mass spectrometry data, comprising:
a mass spectrometer that includes an ion trap and a mass analyzer; and a processor in communication with the mass spectrometer that
receives a mass range and a mass window width parameter for a sample,instructs the mass spectrometer to collect in the ion trap a plurality of ions from the sample that are within the mass range,calculates two or more adjacent or overlapping mass windows that span a mass range using the mass window width parameter, andinstructs the mass spectrometer to eject ions within each mass window of the two or more adjacent or overlapping mass windows from the ion trap and detect a mass spectrum from the ejected ions of the each mass window with the mass analyzer, producing a collection of mass spectra for the mass range.