发明名称 |
METHODS AND COMPOSITIONS FOR REGULATING SRCA2A EXPRESSION LEVELS IN MYOCARDIAL INFARCTION |
摘要 |
The disclosure provides methods and compositions for increasing SERCA2a expression levels in a mammalian subject in need thereof. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide to subjects in need thereof. In some embodiments, the aromatic-cationic peptide is D-Arg-2'6'-Dmt-Lys-Phe-NH2, or a pharmaceutically acceptable salt thereof such as acetate or trifluoroacetate salt. In some embodiments, the subject has suffered a myocardial infarction. |
申请公布号 |
CA2916486(A1) |
申请公布日期 |
2015.01.22 |
申请号 |
CA20142916486 |
申请日期 |
2014.06.24 |
申请人 |
STEALTH BIOTHERAPEUTICS CORP |
发明人 |
WILSON, D. TRAVIS;KLONER, ROBERT A. |
分类号 |
A61K38/07;A61P9/10 |
主分类号 |
A61K38/07 |
代理机构 |
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代理人 |
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地址 |
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