PROCESS FOR PREPARING DIHYDROPYRIDINE DERIVATIVES

摘要

Dihydropyridine derivs. (I)[R, R1, R2=alkyl, cycloalkyl, alkoxyalkyl; R3, R4=H, halo, NO2, CF3, etc.; R5=H, alkyl, aryl, etc.; R6=aryl, pyridyl; Z=O, S, yinylene, etc.; Z1=alkylene; m= 1-3; n=0-2 are prepd. and showed effective hypotensive activities. Thus, a mixt. of m-O2NC6H4CHO, acetoacetate (II) and MeC (NH2):CHCO2Me in Me2CHOH was refluxed for 6 hr to give 75.2% (III).