| 摘要 |
<p>Compounds of formula <IMAGE> (I) wherein R1 or R2 represents a C1-6 alkyl group optionally substituted by one to three halogen atoms and the other represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by one or more substituents selected from halogen atoms and hydroxyl, C1-3 alkyl, C1-3 alkoxy and trifluoromethyl groups; wherein R3 represents a phenyl or pyridyl ring or N-oxide thereof optionally substituted by one or more substituents selected from halogen atoms and hydroxyl, C1-3 alkyl, C1-3 alkoxy and trifluoromethyl groups with the proviso that only one of the groups R1, R2 or R3 represents an optionally substituted pyridyl ring; X represents -CH=CH-; and Z represents <IMAGE> (a) or <IMAGE> (b) wherein R4 represents a hydrogen atom, a carboxyl protecting group or a cation; and R5 represents a hydrogen atom or a C1-3 alkyl group; a solvate thereof, or acid addition salts of compounds wherein R4 represents a hydrogen atom or a carboxyl protecting group; for use in the treatment and/or prevention of diseases associated with hypercholesteroloma and hyperlipoproteinemia.</p> |
