发明名称 |
Quinoxalinyl macrocyclic hepatitis C serine protease inhibitors |
摘要 |
The present invention relates to compounds of Formula (I) or (II), or a pharmaceutically acceptable salt, ester, or prodrug, thereof: formula (I), formula (II): which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. |
申请公布号 |
EP2143727(B1) |
申请公布日期 |
2015.01.21 |
申请号 |
EP20090174877 |
申请日期 |
2004.04.16 |
申请人 |
ENANTA PHARMACEUTICALS, INC. |
发明人 |
NAKAJIMA, SUANNE;SUN, YING;TANG, DATONG;XU, GOUYOU;PORTER, BRIAN;OR, YAT, SUN;WANG, ZHE;MIAO, ZHENWEI |
分类号 |
C07K5/08;A61K;A61K31/00;A61K31/38;A61K31/395;A61P31/12;C07D401/12;C07D409/14;C07D487/04;C07K5/083 |
主分类号 |
C07K5/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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