发明名称 THERAPEUTIC REPLENISHMENT AND ENRICHMENT OF OCULAR SURFACE LUBRICATION
摘要 The present invention provides a pharmaceutical composition, and methods of use thereof, for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes ocular boundary deficiency at the ocular surface. The pharmaceutical composition of the present invention comprises a human PRG4 protein, a lubricant fragment, homolog, or isoform thereof, suspended in an ophthalmically acceptable balanced salt solution. The pharmaceutical composition of the present invention may also comprise one or more ophthalmically acceptable agents selected from the group consisting of an ophthalmically acceptable demulcent. excipient, astringent, vasoconstrictor, emollient, sodium hyaluronate, hyaluronic acid, and surface active phospholipids, in a pharmaceutically acceptable carrier for topical administration.
申请公布号 EP2285364(B1) 申请公布日期 2015.01.21
申请号 EP20090743204 申请日期 2009.04.08
申请人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;SCHEPENS EYE RESEARCH INSTITUTE 发明人 SULLIVAN, BENJAMIN;SCHMIDT, TANNIN, A.;SULLIVAN, DAVID, A.
分类号 A61P27/02;A61K9/00;A61K31/568;A61K31/715;A61K38/13;A61K38/18;A61P27/04 主分类号 A61P27/02
代理机构 代理人
主权项
地址