| 摘要 |
<p>Disclosed is a method for the preparation of omega-arylthioalkanamides, especially omega-imidazolylthioalkanamides, which are useful, for example, in the preparation of certain antihypercholesterolemic agents. The method involves three steps including an addition reaction between a lactone and an amine to produce an omega-hydroxyalkanamide; a condensation reaction between said omega-hydroxyalkanamide and an alkanesulfonic acid halide or anhydride to produce an alkanesulfonate ester; reaction of said alkanesulfonate ester with a salt of an aromatic mercaptan, especially an imidazole-2-thiol, to produce the omega-imidazolylthioalkanamides.</p> |
