发明名称 |
ELECTRO-MICRONEEDLE INTEGRATED BODY FOR IN-SITU CUTANEOUS GENE TRANSFER AND METHOD OF MANUFACTURING SAME |
摘要 |
<p>Provided is an electro-microneedle integrated body in which a dissolving microneedle and an electrode for electroporation are integrated into one, which enables a focused and efficient intracutaneous gene release for percutaneous gene delivery and intracellular gene delivery occurring in one in-situ treatment site The electro-microneedle integrated body according to the present invention includes an electrode for electroporation which is contacted with skin of a human body to apply an electric field pulse, including a base part and a plurality of electrode parts protruding from the base part, and a microneedle adhered to each electrode part and inserted into the skin of a human body, including a biocompatible and biodegradable viscous material and a genetic material, wherein the microneedle degrades within the skin, and the electric field pulse is applied through the electrode for electroporation in a site in which the microneedle is inserted.</p> |
申请公布号 |
EP2737923(A4) |
申请公布日期 |
2015.01.21 |
申请号 |
EP20120818195 |
申请日期 |
2012.07.19 |
申请人 |
RAPHAS CO., LTD.;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY |
发明人 |
JUNG, HYUNGIL;LEE, KWANG;JEONG, DO HYEON;KIM, JUNG DONG |
分类号 |
A61K9/00;A61K48/00;A61M5/158;A61M37/00;A61N1/04;A61N1/05;A61N1/32;B05D5/00 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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