| 摘要 |
PURPOSE:To obtain a new 1-thia-4,6-diazaspiro[4.4]nonane derivative useful as a preventing and treating agent for diseases caused by limited supply of the compound. CONSTITUTION:The objective compound of formula I (X is H, COOH, R<1> or COOR<1>; Y is OH, 0R<1>, A or AOR<1>; R<1> is 1-8C linear or branched hydrocarbon group; A is amino acid residue; AOR<1> is amino acid ester residue) or its pharmaceutically permissible salt, e.g. 7-carboxy-3-{[carboxymethyl)amino]carbonyl-}-1- thia-4,6-diazaspiro[4.4]nonane. This compound can be produced by subjecting a compound of formula II to III to cyclization reaction in a weakly acidic, neutral or alkaline solution and then, as necessary, converting the resultant product into its pharmaceutically permissible salt. Furthermore, the compound of formula I is useful as a preventing or treating agent for above-mentioned diseases, e.g. diabetes mellitus, arrhythmia, ulcer, angina, thrombotic diseases, carcinoma, etc. |
