Potentiator of activity of anti-cancer agent and use thereof, and biomarker for prediction of prognosis in cancer patient and use thereof

摘要

Disclosed is a means for improving the clinical outcomes of cancer therapy. Specifically disclosed is an activity potentiator comprising a compound capable of inhibiting the expression of RFP (RET finger protein) gene or the activity of RFP as an active ingredient. The activity of an anti-cancer agent having an oxidative stress inducing ability can be potentiated by using the anti-cancer agent in combination with the activity potentiator. Further specifically disclosed are a biomarker useful for the recognition of prognosis in a cancer patient and use of the biomarker.

主权项

1. A method for estimating prognosis in a cancer patient having colon carcinoma comprising:
determining an amount of RFP (RET finger protein) in a cancer cell from the patient, and comparing the amount of RFP with a reference amount of RFP wherein an increase in RFP relative to the reference amount is indicative for poor prognosis.