Statin bioavailability enhancement delivery composition

摘要

A composition for increasing the bioavailability of a statin active pharmaceutical ingredient (“API”) in humans and animals, wherein that composition includes a statin API selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin, a first water soluble surfactant having a cloud point greater than about 37° C., a second water soluble surfactant having a cloud point greater than about 37° C., wherein a mixture of the first surfactant and the second surfactant comprises a cloud point less than about 37° C.

主权项

1. A composition for increasing the bioavailability of a statin active pharmaceutical ingredient (“API”) in humans and animals, consisting of:
a statin AP selected from the group consisting of atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin; polyoxyethylene sorbitan monooleate having a cloud point greater than about 37° C.; tocopheryl polyethylene glycol succinate having a cloud point greater than about 37° C.; wherein a mixture of said polyoxyethylene sorbitan monooleate and said tocopheryl polyethylene glycol succinate comprises a cloud point less than about 37° C.