| 主权项 |
1. A generator for a 68Gallium (68Ga) daughter nuclide, wherein the 68Germanium (68Ge) parent nuclide thereof is attached specifically to a support through a trihydroxyphenyl group or a dihydroxyphenyl group and continuously disintegrates to 68Ga by electron capture at a half-life of 270.82d,
wherein the trihydroxyphenyl group or dihydroxyphenyl group is covalently bound via a linker to a support material, the support material is selected from the group consisting of: inorganic inert oxide materials, in particular silica gel, SiO2, TiO2, SnO2, Al2O3, ZnO, ZrO2, HfO2, organic inert polymers and copolymers, in particular styrene-divinylbenzene, polystyrene, styrene-acrylonitrile, styrene-acrylonitrile-methylmethacrylate, acrylonitrile-methylmethacrylate, polyacrylonitrile, polyacrylates, acrylic or methacrylic esters, acrylonitrile-unsaturated dicarboxylic acid-styrene, vinylidene chloride-acrylonitrile, and the linker being selected from the group consisting of: C2 to C20 esters; C2 to C20 alkyls, phenyl, thiourea, C2-C20 amines, maleimide, melamine, trihydroxyphenyl alkoxsilanes, in particular 1,2,3-trihydroxyphenyltriethoxysilane, 1,2,3-trihydroxyphenyldiethoxysilane, 1,2,3-trihydroxyphenylethoxysilane, 1,2,3-trihydroxyphenyltripropoxysilane, 1,2,3-trihydroxyphenylchlorosilane, epichlorohydrin, isothiocyanates, thiols, wherein the trihydroxyphenyl group is 1,2,3-trihydroxybenzene (pyrogallol). |
