Parakeratosis inhibitor, pore-shrinking agent and external composition for skin

摘要

The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin-inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent comprises one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent.

主权项

1. A method of inhibiting parakeratosis by applying to skin a composition comprising one or more p-alanine derivatives selected from the group consisting of:
3-(1′-piperidine)-propionic acid, N-monomethyl-β-alanine, N-cyclohexyl-β-alanine, N-cyclohexylmethyl-β-alanine, N-cyclohexyl-N-methyl-β-alanine, N-cyclohexylcarbonyl-β-alanine, N-(2′-pyridyl)-β-alanine, N-benzyl-β-alanine, N-β-anisoyl-β-alanine (N-4′-methoxybenzoyl-β-alanine), N-m-anisoyl-β-alanine (N-3′-methoxybenzoyl-β-alanine), N-o-anisoyl-β-alanine (N-2′-methoxybenzoyl-β-alanine), N-3′,4′,5′-trimethoxybenzoyl-β-alanine, and N-phenylacetyl-β-alanine, as well as a salt thereof.