Use of the cathelicidin LL-37 and derivatives thereof for wound healing

摘要

Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.

主权项

1. A method for the treatment of chronic leg ulcers due to venous insufficiency, comprising administering a peptide LL-37 (SEQ ID NO: 1) or a pharmaceutically acceptable salt thereof to a subject in need of such treatment.