Antibiotic compositions for the treatment of gram negative infections

摘要

Provided herein is an antibacterial compound of the following formula:;
or a pharmaceutically acceptable salt thereof. The antibacterial compound has antibacterial properties against a diverse range of gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin B. Also provided are antibacterial pharmaceutical compositions containing the antibacterial compound, as well as methods for preparing the antibacterial compound.

主权项

1. A method for treating a bacterial lung or respiratory infection including a gram-negative bacteria, the method comprising administering to a subject in need thereof a therapeutically effective amount of an antibacterial compound of the Formula: or a pharmaceutically acceptable salt thereof.