发明名称 |
Inhibitor of protein crosslinking and use of the same |
摘要 |
The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3:;
wherein R1 is a substituted or unsubstituted aryl or heterocyclyl group, R2, R3, and R4 are hydrogen atoms, n is 2, X is halogen, R5 and R6 independently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein R5 and R6 are not hydrogen atoms at the same time, or R5 and R6 may be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor. |
申请公布号 |
US8937091(B2) |
申请公布日期 |
2015.01.20 |
申请号 |
US201013508247 |
申请日期 |
2010.05.19 |
申请人 |
Japan Science and Technology Agency |
发明人 |
Mikoshiba Katsuhiko;Hamada Kozo;Terauchi Akiko;Ozaki Shouichirou;Goto Jun-ichi;Ebisui Etsuko;Suzuki Akinobu |
分类号 |
A61K31/45;C07D295/10;A61K31/045;A61K31/085;A61K31/12;A61K31/136;A61K31/137;A61K31/216;A61K31/341;A61K31/36;A61K31/381;A61K31/40;A61K31/417;A61K31/426;A61K31/4402;A61K31/4406;A61K31/4409;A61K31/4439;A61K31/444;A61K31/4453;A61K31/4545;A61K31/496;A61K31/4965;A61K31/5375;A61K31/55 |
主分类号 |
A61K31/45 |
代理机构 |
Foley & Lardner LLP |
代理人 |
Foley & Lardner LLP |
主权项 |
1. A compound represented by the following Formula (3):wherein:
R1 is pyridyl, which is optionally substituted with C1-C4 alkyl or halogen; R2, R3, and R4 are hydrogen atoms; R5 is benzyl; and R6 is hydrogen, C1-C4 alkyl, or hydroxyl C1-C4 alkyl. |
地址 |
Saitama JP |