| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to a method for preparing a solid form of the compound gadobenate dimeglumine of formula(I) used as a contrast agent for diagnostic visualisation, particularly in magnetic resonant tomography. The presented method involves spray drying of a liquid composition of the above compound. Preferentially, the liquid composition represents an aqueous solution. The invention also refers to a solid powder form of gadobenate dimeglumine prepared by the method described above, a pharmaceutical kit containing this form, and a method for preparing a solid form of 4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl-2-oxa-5,8,11-triazatridecane-13 acid.EFFECT: method enables preparing the high-yield and reproducible solid form of gadobenate dimeglumine, which possesses good flowability and dissolution rate.15 cl, 3 ex |
