Biocompatible drug delivery apparatus and methods

摘要

Apparatus and methods for treatment of an internal cavity are provided. The internal cavity is coated with a treatment solution. The treatment solution can include a solidifiable matrix with or without a drug or combination of drugs incorporated therein, or a drug solution without a solidifiable matrix. The treatment solution is coated onto at least a portion of the internal cavity, and acts as a slow-release drug delivery system.

主权项

1. A system adapted to deliver a hydrogel based biocompatible matrix to an internal cavity and to treat said internal cavity by coating preselected areas in the surface of said internal cavity with said hydrogel based biocompatible matrix, the system comprising:
a. a delivery device comprising a body having a proximal end and a distal end; b. at least one balloon positioned on said distal end of said body; wherein said balloon is characterized by an outer surface; and c. at least one external channel on said outer surface of said balloon; wherein said external channel is movable with respect to said balloon; wherein said at least one external channel is adapted to at least partially accommodate at least a portion of said hydrogel based biocompatible matrix, such that application of predetermined amount of pressure on the same results in the release of at least a portion of said hydrogel based biocompatible matrix from said at least one external channel onto said preselected areas such that when said balloon is inflated, the same coats said preselected areas in said surface with hydrogel based biocompatible matrix.