发明名称 |
HETEROCYCLIC BORONIC ACID COMPOUNDS |
摘要 |
Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I:
wherein n is 1 to 3; X is CH 2 ; S; O; CF 2 or C(CH 3 ) 2 ; Z is H; halogen; hydroxyl; (C 1-6 )alkoxy; (C 1-12 )alkyl; (C 3-12 )cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R 7 ; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CR i R ii , R 1 , R 2 , R 3 , R 4 and R 5 are as described herein. |
申请公布号 |
HRP20141155(T1) |
申请公布日期 |
2015.01.16 |
申请号 |
HR2014P001155T |
申请日期 |
2014.11.27 |
申请人 |
SINO-MED INTERNATIONAL ALLIANCE, INC. |
发明人 |
CAMPBELL, DAVID ALAN;WINN, DAVID |
分类号 |
A61P3/10;A61K31/69;C07F5/02 |
主分类号 |
A61P3/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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