A PREPARATION METHOD OF PHOSPHORIC MONOESTER COMPOUND OF ACYCLIC NUCLEOSIDE ANTIVIRAL DRUGS

摘要

Provided is a method for preparing an acyclic nucleoside monophosphate compound as an antiviral drug, which comprises reacting an acyclic nucleoside antiviral drug such as adefovir or tenofovir as a raw material, with a aliphatic long-chain alkoxy-ethanol/propanol, to obtain a target compound. The present invention overcomes the disadvantage in the prior art, not only improves the quality of adefovir or tenofovir monophosphate, but also reduces the production cost, and meanwhile has the advantages of being convenient in operation and being easy for industrial production.