| 发明名称 |
2,4- OR 4,6-DIAMINOPYRIMIDINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER |
| 摘要 |
Provided are compounds of formula (I), wherein: ring A and ring B are each independently an optionally substituted 5-6 membered monocyclic aryl or heteroaryl; one of X, Y and W is CH and the two others are N; and Z is H or -C(R1)(R2)(R3). The compounds are inhibitors of isocitrate dehydronenase 2 (IDH2) mutants useful for treating cancer. |
| 申请公布号 |
WO2015006591(A1) |
申请公布日期 |
2015.01.15 |
| 申请号 |
WO2014US46202 |
申请日期 |
2014.07.10 |
| 申请人 |
AGIOS PHARMACEUTICALS, INC. |
发明人 |
KONTEATIS, ZENON, D.;POPOVICI-MULLER, JANETA;TRAVINS, JEREMY |
| 分类号 |
C07D239/48;A61K31/505;A61P35/00;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D405/12;C07D405/14;C07D413/04;C07D413/12;C07D413/14;C07D417/04;C07D417/12;C07D493/08 |
主分类号 |
C07D239/48 |
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