发明名称 |
MUTATED IMMUNOGLOBULIN-BINDING POLYPEPTIDES |
摘要 |
The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides. |
申请公布号 |
WO2015005859(A1) |
申请公布日期 |
2015.01.15 |
申请号 |
WO2014SE50872 |
申请日期 |
2014.07.08 |
申请人 |
GE HEALTHCARE BIO-SCIENCES AB |
发明人 |
RODRIGO, GUSTAV;ANDER, MATS;BAURÉN, GÖRAN;BJÖRKMAN, TOMAS |
分类号 |
C07K14/31;B01D15/38;C07K1/22;C12N15/00 |
主分类号 |
C07K14/31 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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