DIFFERENTIATION OF PLURIPOTENT STEM CELLS AND CARDIAC PROGENITOR CELLS INTO STRIATED CARDIOMYOCYTE FIBERS USING LAMININS LN-511, LN-521 AND LN-221
摘要
The present disclosure describes methods of differentiating cardiomyocyte progenitor cells and mature cardiomyocyte cells from pluripotent stem cells. The methods may include differentiating pluripotent stems cells on a substrate including (i) laminin-511 or 521 and (ii) laminin 221. The mature cardiomyocyte cells produced by the method may form a human heart muscle cell line for use in regenerative cardiology.
申请公布号
WO2015004539(A2)
申请公布日期
2015.01.15
申请号
WO2014IB02289
申请日期
2014.07.02
申请人
NATIONAL UNIVERSITY OF SINGAPORE;BIOLAMINA AB
发明人
TRYGGVASON, KARL;YAP, YAN, WEN;YI, SUN;TRYGGVASON, KRISTIAN