| 摘要 |
PROBLEM TO BE SOLVED: To elucidate a series of compounds grounded on 3-deazaneplanocin A (DZNep) core structures and designed for inhibiting functions of polycomb inhibitory complex 2 (PRC2) protein.SOLUTION: As compounds expressed by the structural formula I or enantiomers or diastereomers of the same or salts of any of them, members of the compounds, enantiomers, diastereomers, or salts which are compounds other than (1R, 2S, 3R)-3-(6-amino-9H-purine-9-yl)cyclopentane-1,2-diol or (1R, 2S, 3R)-3-(4-amino-1H-imidazo[4,5-c]pyridine-1-yl)cyclopentane-1,2-diol or (±)-(1R, 2S, 3R)-3-(6-amino-9H-purine-9-yl)-1,2-cyclopentanediol hydrochloride or 3-deaza-asteromycin and which exhibit activities of activating at least approximately 15% of E2F1 derivative apoptosis are provided. |
