N-CONTAINING HETEROCYCLIC COMPOUNDS

摘要

The present invention relates to N-containing heterocyclic compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2, JAK3 or TYK2 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

主权项

1. A compound of formula I wherein Q, W and Y are independently selected from N and CR2; Z is NR2 or S; L is absent, CO, SO2 or substituted or unsubstituted C1-6alkylene; A and B are independently absent or substituted or unsubstituted C1-6alkylene wherein one or more carbon atoms can be optionally replaced with O, CO, NR2, NR2CO, CONR2, NR2SO2, SO2NR2, S and/or S(O)n; R1 is independently selected from H, substituted or unsubstituted C1-6alkyl, substituted or unsubstituted C2-6alkenyl, substituted or unsubstituted C2-6alkynyl, substituted or unsubstituted C1-6alkoxy, OH, halogen, CN, NO2, NR2R3, SO2R3, SO2NR2R3, CF3, OCF3, NR2SO2R3, CO2R3, COSR3, CSR3, COR3, NR2, CSR3, NR2CSR3, CONR2R3, NR2COR3, NR2CONR2R3, SO3R3, substituted or unsubstituted C3-8cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl having up to 3 heteroatoms selected from N, O, S and SO2; R is selected from H, substituted or unsubstituted C1-6alkyl, substituted or unsubstituted C2-6alkenyl, substituted or unsubstituted C2-6alkynyl, substituted or unsubstituted C1-6alkoxy, OH, halogen, CN, NO2, CO2R3, CONR2R3, NR2COR3, SO3R3, C3-8cycloalkyl, aryl and heterocyclyl having up to 3 heteroatoms selected from N, O, S and SO2, each of which may be substituted with up to 3 substituents independently selected from substituted or unsubstituted C1-6alkyl, substituted or unsubstituted C2-6alkenyl, substituted or unsubstituted C2-6alkynyl, substituted or unsubstituted C1-6alkoxy, OH, OCF3, halogen, CN, NO2, NR2R3, SO2R3, SO2NR2R3, NR2SO2R3, CO2R3, COR3, NR2COR3, R2NHCO2R3, CONR2R3, NR2CONR2R3 and substituted or unsubstituted heterocyclyl having up to 3 heteroatoms selected from N, O, S and SO2; R2 and R3 are independently selected from H, substituted or unsubstituted C1-6alkyl, substituted or unsubstituted C2-6alkenyl, substituted or unsubstituted C2-6alkynyl, substituted or unsubstituted C1-6alkoxy, CN, substituted or unsubstituted C3-8cycloalkyl, substituted or unsubstituted aryl and substituted or unsubstituted heterocyclyl having up to 3 heteroatoms selected from N, O, S and SO2; m is 1 to 3; and n is 1 or 2; salts, isomers and/or prodrugs thereof.