| 发明名称 |
3B-HYDROXYSTEROID DEHYDROGENASE IN STEROID-DEPENDENT DISEASE |
| 摘要 |
Methods and kits for characterizing a subject having a steroid-dependent disease such as prostate cancer are described. A method of treating a steroid-dependent disease in a subject by obtaining a biological sample from the subject, determining if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed in the biological sample, and providing treatment other than or in addition to steroid ablation to the subject if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed is also described. |
| 申请公布号 |
US2015018323(A1) |
申请公布日期 |
2015.01.15 |
| 申请号 |
US201414330177 |
申请日期 |
2014.07.14 |
| 申请人 |
THE CLEVELAND CLINIC FOUNDATION |
发明人 |
Sharifi Nima;Chang Kai-Hsiung |
| 分类号 |
C12Q1/68;G01N33/574;C07K16/40;A61K31/58;A61K31/4166 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating a steroid-dependent disease in a subject in need thereof, comprising:
obtaining a biological sample from the subject, determining if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed in the biological sample, and providing treatment other than or in addition to steroid ablation to the subject if the HSD3B1(1245C) gene or 3βHSD1(367T) protein is expressed. |
| 地址 |
Cleveland OH US |
