| 主权项 |
1. A polyvalent synthetic compound comprising a support on which at least 3 pseudopeptide units are grafted, said compound being of formula (I): wherein
each X independently represents any amino acid;Y1 and Y2 are selected independently from amino acids having a basic side chain;Z is selected from: proline, optionally substituted at γ, β or δ by hydroxyl, amine, C1-C10 alkyl, C1-C10 alkenyl, C1-C10 alkynyl, C5-C12 aryl, C5-C14 aralkyl, or C5-C12 heteroaryl groups, these groups being themselves optionally substituted by 1 to 6 substituents selected from a halogen atom, NO2, OH, C1-C4 alkyl, NH2, CN, trihalomethyl, C1-C4 alkoxyl, C1-C4 dialkylamino, guanidino group, thio group; N-alkylamino acid; dialkylamino acid; cyclic dialkylamino acid; and pipecolic acid or derivatives thereof;n and I are independently 0 or 1;m is an integer between 0 and 3;k is an integer greater than or equal to 3; andΨ represents a modified peptide bond significantly more resistant to at least one protease than a standard peptide bond. |
