| 发明名称 |
FC-RECEPTOR BASED AFFINITY CHROMATOGRAPHY |
| 摘要 |
Herein is reported the use of an immobilized non-covalent complex of a neonatal Fc receptor (FcRn) and beta-2-microglobulin (b2m) as affinity chromatography ligand in general and, for example, for the determination of the in vivo half-live of an antibody by determining the ratio of the retention times of the antibody and a reference antibody. |
| 申请公布号 |
US2015018241(A1) |
申请公布日期 |
2015.01.15 |
| 申请号 |
US201314378808 |
申请日期 |
2013.02.14 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
Falkenstein Roberto;Hertenberger Hubert;Rueger Petra;Schlothauer Tilman |
| 分类号 |
C07K1/22;G01N33/68;B01J39/26;C07K16/06 |
主分类号 |
C07K1/22 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Method of using an immobilized non-covalent complex of a neonatal Fc receptor (FcRn) and beta-2-microglobulin (b2m) as an affinity chromatography ligand in an affinity chromatography with a positive linear pH gradient. |
| 地址 |
Nutley NJ US |
