| 发明名称 |
ADJUVANT FORMULATIONS COMPRISING TLR4 AGONISTS AND METHODS OF USING THE SAME |
| 摘要 |
Formulations and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed. The formulations generally comprise a TLR4 agonist and a metabolizable oil at a concentration of about 0.01%-1% v/v, wherein the hydrophobic:lipophilic balance (HLB) of the emulsion is greater than about 9. |
| 申请公布号 |
US2015017191(A1) |
申请公布日期 |
2015.01.15 |
| 申请号 |
US201314377488 |
申请日期 |
2013.02.07 |
| 申请人 |
Infectious Disease Research Institute |
发明人 |
Fox Christopher;Reed Steven G.;Baldwin Susan;Vedvick Thomas |
| 分类号 |
A61K9/113;A61K47/26;A61K47/24;A61K39/00;A61K39/39 |
主分类号 |
A61K9/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An oil-in-water emulsion comprising a TLR4 agonist and a metabolizable oil, wherein the metabolizable oil is present in the oil-in-water emulsion at a concentration of about 0.01%-1% v/v, and wherein the hydrophobic:lipophilic balance (HLB) of the oil-in-water emulsion is greater than about 9. |
| 地址 |
Seattle WA US |
