USE OF EPITOPES INDUCING SPECIFIC TOLERANCE FOR THE PREVENTION OF TISSUE REJECTION

摘要

The present invention relates to a composition for use in the prevention of the rejection of skin tissue, comprising an effective amount of a peptide comprising an epitope of an antigen selected from the group of the polypeptides type XVII collagen, VII collagen, integrin alpha 6, integrin beta 4, chains of laminin, chains of laminin 322, type IV collagen, plectin, plakoglobin, bullous pemphigoid antigen 1, periplakin, envoplakin, desmoglein 1, desmoglein 3, a desmocollin and human bullous pemphigoid antigen 2 (hBPAG2) wherein said epitope induces immunological tolerance against its underlying polypeptide, and/or a nucleic acid for expressing a peptide comprising an epitope of said antigen as well as a gene therapy based on the composition, in the context of autoimmune blistering diseases, such as bullous pemphigoid or genetic skin diseases such as epidermolysisbullosa.

主权项

1. A composition for use in the prevention of the rejection of skin tissue, comprising an effective amount of:
a) a peptide comprising an epitope of an antigen selected from type XVII collagen, type VII collagen, integrin alpha 6, integrin beta 4, chains of laminin, chains of laminin 322, type IV collagen, plectin, plakoglobin, bullous pemphigoid antigen 1, periplakin, envoplakin, desmoglein 1, desmoglein 3, a desmocollin and human bullous pemphigoid antigen 2 (hBPAG2), wherein said epitope induces immunological tolerance against its underlying polypeptide, and/or b) a nucleic acid for expressing a peptide comprising an epitope of said antigen, and wherein said epitope is not the full length polypeptide.