COMPOSITIONS AND METHODS FOR PROLONGING PREGNANCY

摘要

Provided are compositions and methods for use for prolonging pregnancy. The methods involve administering to an individual in need thereof an effective amount of a composition that contains a compound which is capable of specifically binding to an alpha2delta subunit of a voltage-gated calcium channel, such as gabapentin, pregabalin, and pharmaceutically acceptable salts and prodrugs thereof The composition is administered such that pregnancy is prolonged to by reducing, stopping, preventing and/or preventing recurrence of preterm labor during a human pregnancy. Also provides are articles of manufacture that have packaging containing one or a combination of compounds that are capable of specifically binding an alpha2delta subunit of a voltage-gated calcium channel. The compound is provided in an amount sufficient for alleviating and/or preventing preterm labor in a pregnant human female. The packaging comprises printed material, the printed material providing an indication that the pharmaceutical composition is for use in the alleviating or preventing of preterm labor and/or for prolonging pregnancy.

主权项

1. A method for prolonging pregnancy in a pregnant human female experiencing preterm labor or at risk for recurrence of a subsequent preterm labor during the pregnancy, the method comprising administering to the pregnant human female an effective amount of a composition comprising an active ingredient, wherein the active ingredient is selected from gabapentin, pregabalin, and pharmaceutically acceptable salts or prodrugs thereof