COMPOSITIONS, METHODS & SYSTEMS FOR RESPIRATORY DELIVERY OF TWO OR MORE ACTIVE AGENTS

摘要

Compositions, methods and systems are provided for pulmonary or nasal delivery of two or more active agents via a metered dose inhaler. In one embodiment, the compositions include a suspension medium, active agent particles, and suspending particles, in which the active agent particles and suspending particles form a co-suspension within the suspension medium.

主权项

1. A method for treating a pulmonary disease or disorder in a patient, the method comprising:
providing a pharmaceutically acceptable co-suspension, the co-suspension comprising:
a suspension medium comprising a pharmaceutically acceptable propellant;two or more active agents;one or more species of respirable active agent particles; andone or more species of respirable suspending particles, wherein the active agent particles and suspending particles associate to form a co-suspension within the suspension medium; and administering the co-suspension to the patient as a respirable aerosol, wherein said administering of the co-suspension comprises delivering a therapeutically effective amount of the two or more active agents to the patient.