FUSED AMINO PYRIDINES FOR THE TREATMENT OF BRAIN TUMORS

摘要

The present invention relates to the use of compounds with fused amino pyridine core for the treatment of malignancies associated with brain and lung. The oral administration of compounds of the instant application results in effective brain penetration and provides for non-intrusive treatment of brain and lung tumors.

主权项

1. A method of treating lung cancer comprising the oral administration of a compound of formula I: or its pharmaceutically acceptable salts thereof, wherein; n is 1 or 2; R1 and R2 are independently H, C1-C8 alkyl, or C1-C8 substituted alkyl; R3 and R4 are independently H, C1-C8 alkyl, or C1-C8 substituted alkyl; R5 is halogen, —SR6 or —NR6R7 wherein R6 and R7 are independently H, C1-C8 alkyl, C1-C8 substituted alkyl, C2-C8 alkenyl, C2-C8 substituted alkenyl, C2-C8 alkynyl, C2-C8 substituted alkynyl or C3-C8 cycloalkyl; and, Y is C1-C8 alkyl, C1-C8 substituted alkyl, C2-C8 alkenyl, C2-C8 substituted alkenyl, C2-C8 alkynyl, C2-C8 substituted alkynyl, C3-C8 cycloalkyl or C3-C8 substituted cycloalkyl.