主权项 |
1. A method for treating a condition selected from the group of neurodegenerative diseases, diabetes, cancer and stress, said method comprising administering an effective amount of at least one compound of formula (I) wherein R1 denotes Y, COA, COOA, COO—(CH2)n—Ar or COO—(CH2)n-Cyc; R2, R3 denote independently from one another Y or SO2Y; R4 denotes Cl, Br, I, COOY, SO2Y, CN, CAr3, (CH2)m—Ar, R5 denotes (CH2)n—Ar, (CH2)n-Cyc, (CH2)n-Het, (CH2)n—O—Ar,
(CH2)n—CY(OH)—Ar, (CH2)n—CO—Ar or (CH2)n—NY—Ar; X denotes CH2, CO or CH(OH); Y denotes H or A; A denotes unbranched or branched alkyl having 1-10C atoms, in which 1-7H atoms can be replaced independently from one another by Hal or in which one CH2 group can be replaced by a —CH═CH— group; Cyc denotes cycloalkyl having 3-7C atoms, in which 1-4H atoms can be replaced independently from one another by Hal or which can be substituted by Ar; Ar denotes an unsaturated or aromatic mono- or bicyclic carbocycle having 3-12C atoms, which can be substituted by at least one substituent selected from the group of Hal, A, (CY2)n—OY, (CY2)n—NYY, COOY, CONYY, NHCOY, SO2Y, CN and phenoxy; Het denotes an unsaturated or aromatic mono-, bi- or tricyclic heterocycle having 1-12C atoms and 1-4 N atoms, which can be substituted by at least one substituent selected from the group of Hal, A, (CY2)n—OY, (CY2)n—NYY, COOY, CONYY, NHCOY, SO2Y, SO2Ar, CN and thiophenyl; Hal denotes F, Cl, Br or I; m denotes 1, 2 or 3; and n denotes 0, 1, 2, 3, 4, 5 or 6; or a physiologically acceptable salt thereof to a mammal in need of such treatment. |