发明名称 |
COMPOSITIONS AND METHODS FOR TREATING CANCER |
摘要 |
The present invention provides combination therapies useful for treating cancer, particularly breast cancer. The invention provides, in various embodiments, methods of treating a cancer, comprising administering to a patient afflicted therewith of an effective amount an immunoconjugate comprising a monoclonal antibody moiety and a first pro-apoptotic drug moiety linked thereto; and administering to the patient an effective amount of a second pro-apoptotic drug. The monoclonal antibody moiety of the immunoconjugate can act to target receptors of hormone-resistant breast cancer cells, such as HER2. Synergistic effects can be seen when the two pro-apoptotic drugs, acting by a common molecular mechanism (vertical modulation) or different molecular mechanisms (horizontal modulation) are administered to patients afflicted by breast cancer, such as hormone-resistant breast cancer. |
申请公布号 |
EP2707020(A4) |
申请公布日期 |
2015.01.14 |
申请号 |
EP20120782335 |
申请日期 |
2012.05.09 |
申请人 |
UNIVERSITY OF VIRGINIA PATENT FOUNDATION |
发明人 |
SANTEN, RICHARD J.;AIYER, SARAH E. |
分类号 |
A61K39/00;A61K31/165;A61K31/353;A61K31/537;A61K31/565;A61K31/60;A61K47/48;C07K1/00;C07K16/00 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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